Gains in Power from Structured Two-Sample Tests of Means on Graphs

  title={Gains in Power from Structured Two-Sample Tests of Means on Graphs},
  author={Laurent Jacob and Pierre Neuvial and Sandrine Dudoit},
We consider multivariate two-sample tests of means, where the location shift between the two populations is expected to be related to a known graph structure. An important application of such tests is the detection of differentially expressed genes between two patient populations, as shifts in expression levels are expected to be coherent with the structure of graphs reflecting gene properties such as biological process, molecular function, regulation, or metabolism. For a fixed graph of… CONTINUE READING


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