Gaining efficiency by parallel quantification and identification of iTRAQ-labeled peptides using HCD and decision tree guided CID/ETD on an LTQ Orbitrap.

@article{Mischerikow2010GainingEB,
  title={Gaining efficiency by parallel quantification and identification of iTRAQ-labeled peptides using HCD and decision tree guided CID/ETD on an LTQ Orbitrap.},
  author={Nikolai Mischerikow and Pim van Nierop and Ka Wan Li and H. -G. Bernstein and August B. Smit and Albert J. R. Heck and A F Maarten Altelaar},
  journal={The Analyst},
  year={2010},
  volume={135 10},
  pages={2643-52}
}
Isobaric stable isotope labeling of peptides using iTRAQ is an important method for MS based quantitative proteomics. Traditionally, quantitative analysis of iTRAQ labeled peptides has been confined to beam-type instruments because of the weak detection capabilities of ion traps for low mass ions. Recent technical advances in fragmentation techniques on linear ion traps and the hybrid linear ion trap-orbitrap allow circumventing this limitation. Namely, PQD and HCD facilitate iTRAQ analysis on… CONTINUE READING

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