Gain of virulence caused by loss of a gene in murine cytomegalovirus.

@article{Bubi2004GainOV,
  title={Gain of virulence caused by loss of a gene in murine cytomegalovirus.},
  author={Ivan Bubi{\'c} and Markus Wagner and Astrid Krmpotic and Tanja Saulig and Sungjin Kim and Wayne M Yokoyama and Stipan Jonji{\'c} and Ulrich Koszinowski},
  journal={Journal of virology},
  year={2004},
  volume={78 14},
  pages={7536-44}
}
Mouse strains are either resistant or susceptible to murine cytomegalovirus (MCMV). Resistance is determined by the Cmv1(r) (Ly49h) gene, which encodes the Ly49H NK cell activation receptor. The protein encoded by the m157 gene of MCMV has been defined as a ligand for Ly49H. To find out whether the m157 protein is the only Ly49H ligand encoded by MCMV, we constructed the m157 deletion mutant and a revertant virus. Viruses were tested for susceptibility to NK cell control in Ly49H+ and Ly49H… CONTINUE READING