Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.

@article{FernndezFernndez2004GainoffunctionMI,
  title={Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.},
  author={Jos{\'e} M Fern{\'a}ndez-Fern{\'a}ndez and Marta Tom{\'a}s and E. Brozos V{\'a}zquez and Patricio Orio and Ram{\'o}n Latorre and Mariano Sent{\'i} and Jaume Marrugat and M. A. Lopez Valverde},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 7},
  pages={1032-9}
}
Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca(2+)-dependent K(+) (BK) channel. The BK channel in vascular smooth muscle is formed by an ion-conducting alpha subunit and a regulatory beta(1) subunit, which couples local increases in intracellular Ca(2+) to augmented channel activity and vascular relaxation. Our large population-based genetic epidemiological… CONTINUE READING
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