Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.

@article{Acin2011GainoffunctionMP,
  title={Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.},
  author={Sergio Acin and Zhongyou Li and Olga M Mej{\'i}a and Dennis R. Roop and A El-naggar and Carlos Caulin},
  journal={The Journal of pathology},
  year={2011},
  volume={225 4},
  pages={479-89}
}
Mutations in p53 occur in over 50% of the human head and neck squamous cell carcinomas (SCCHN). The majority of these mutations result in the expression of mutant forms of p53, rather than deletions in the p53 gene. Some p53 mutants are associated with poor prognosis in SCCHN patients. However, the molecular mechanisms that determine the poor outcome of cancers carrying p53 mutations are unknown. Here, we generated a mouse model for SCCHN and found that activation of the endogenous p53 gain-of… CONTINUE READING
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