Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site.

  title={Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site.},
  author={Kris Richardson and Jennifer A. Nettleton and Noemi Rotllan and Toshiko Tanaka and Caren E. Smith and Chao-Qiang Lai and Laurence D. Parnell and Yu-Chi Lee and Jari Lahti and Rozenn N Lemaitre and Ani Manichaikul and Margaux F. Keller and Vera Mikkil{\"a} and Julius Suh Ngwa and Frank J. A. van Rooij and Christie M Ballentyne and Ingrid B. Borecki and L. Adrienne Cupples and Melissa J Garcia and Albert Hofman and Luigi Ferrucci and Dariush Mozaffarian and M E Per{\"a}l{\"a} and Olli Raitakari and Russell P Tracy and Donna K Arnett and Stefania Bandinelli and Eric Boerwinkle and Johan G Eriksson and O. H. Franco and Mika K{\"a}h{\"o}nen and Michael A. Nalls and David S Siscovick and Denise K. Houston and Bruce M. Psaty and Jorma Viikari and Jacqueline C. M. Witteman and Mark O Goodarzi and Terho Lehtim{\"a}ki and Yongmei Liu and M C Carola Zillikens and Yii-Der I. Chen and Andr{\'e} G. Uitterlinden and Jerome I. Rotter and Carlos Fern{\'a}ndez-Hernando and Jos{\'e} M. Ordov{\'a}s},
  journal={American journal of human genetics},
  volume={92 1},
Genome-wide association studies (GWAS) have identified hundreds of genetic variants that are associated with lipid phenotypes. However, data supporting a functional role for these variants in the context of lipid metabolism are scarce. We investigated the association of the lipoprotein lipase (LPL) variant rs13702 with plasma lipids and explored its potential for functionality. The rs13702 minor allele had been predicted to disrupt a microRNA (miR) recognition element (MRE) seed site (MRESS… CONTINUE READING
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A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS

  • K. Richardson, Lai, +4 authors J. M. Ordovas
  • BMC Genomics
  • 2011

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