Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma.

@article{Tanaka2008GainOG,
  title={Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma.},
  author={Yasuo Tanaka and Fumihiko Kanai and Motohisa Tada and Ryosuke Tateishi and Masashi Sanada and Yasuhito Nannya and Miki Ohta and Yoshinari Asaoka and Motoko Seto and Shuichiro Shiina and Haruhiko Yoshida and Takao Kawabe and Osamu Yokosuka and Seishi Ogawa and Masao Omata},
  journal={Journal of hepatology},
  year={2008},
  volume={49 5},
  pages={746-57}
}
BACKGROUND/AIMS The aim of this study is to identify genomic changes that might be implicated in hepatocellular carcinoma (HCC) progression, and evaluate the associations with clinico-pathological features. METHODS The genomic DNA of 17 hepatoma cell lines was analyzed using Affymetrix GeneChip Human Mapping 50K high-density oligonucleotide arrays. We selected representative genes from recurrent amplified regions and measured the copy number of these genes in 70 HCC clinical samples… CONTINUE READING