Gain-of-Function Screen for Genes That Affect Drosophila Muscle Pattern Formation

  title={Gain-of-Function Screen for Genes That Affect Drosophila Muscle Pattern Formation },
  author={Nicole Staudt and Andreas Molitor and K{\'a}lm{\'a}n Somogyi and Juan Mata and Silvia Curado and Karsten G Eulenberg and Martin Meise and Thomas Siegmund and Thomas H{\"a}der and Andres Hilfiker and Guenter Br{\"o}nner and Anne Ephrussi and Pernille R\orth and Stephen Michael Cohen and Sonja Fellert and Ho-Ryun Chung and Olaf Piepenburg and Ulrich Sch{\"a}fer and Herbert Jaeckle and Gerd Vorbrueggen},
  journal={PLoS Genetics},
  pages={2185 - 2195}
This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes that affect embryonic muscle pattern formation. We designed a UAS/GAL4 system to drive GAL4-responsive expression of the EP-targeted genes in developing apodeme cells to which migrating myotubes finally attach and in an intrasegmental pattern of cells that serve myotubes as a migration substrate on… CONTINUE READING

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