Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL.

Abstract

Gain of 20q11.21 is a chromosomal abnormality that is recurrently found in human pluripotent stem cells and cancers, strongly suggesting that this mutation confers a proliferative or survival advantage to these cells. In this work we studied three human embryonic stem cell (hESC) lines that acquired a gain of 20q11.21 during in vitro culture. The study of… (More)
DOI: 10.1093/molehr/gat077

Topics

2 Figures and Tables

Slides referencing similar topics