Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.

@article{Harder2001GainAL,
  title={Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.},
  author={Kenneth W. Harder and Linda M Parsons and Jane Armes and Nichoals Evans and Nicole Kountouri and Ross Clark and Cathy Quilici and Dianne Grail and Graham S. Hodgson and Ashley R. Dunn and Margaret L. Hibbs},
  journal={Immunity},
  year={2001},
  volume={15 4},
  pages={603-15}
}
To investigate the role of the Lyn kinase in establishing signaling thresholds in hematopoietic cells, a gain-of-function mutation analogous to the Src Y527F-activating mutation was introduced into the Lyn gene. Intriguingly, although Lyn is widely expressed within the hematopoietic system, these mice displayed no propensity toward hematological malignancy. By contrast, analysis of aging cohorts of both loss- and gain-of-function Lyn mutant mice revealed that Lyn(-/-) mice develop splenomegaly… CONTINUE READING

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