Gaegurin 4, a peptide antibiotic of frog skin, forms voltage-dependent channels in planar lipid bilayers.

@article{Kim1999Gaegurin4A,
  title={Gaegurin 4, a peptide antibiotic of frog skin, forms voltage-dependent channels in planar lipid bilayers.},
  author={H J Kim and Suk Kyu Han and Jin Bong Park and Hea Ja Baek and Byeong Jae Lee and Pan Dong Ryu},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  year={1999},
  volume={53 1},
  pages={
          1-7
        }
}
Gaegurin 4 (GGN4) is a cationic peptide of 37 amino acids (MW 3748) isolated from the skin of Rana rugosa. It has shown a broad spectrum antimicrobial activity in vitro against Gram-negative and -positive bacteria, fungi and protozoa. To understand its mechanism of antimicrobial action, we examined the effect of GGN4 on the membrane conductance and the electrical properties of GGN4-induced pores in planar lipid bilayers under voltage clamp. Natural and synthetic GGN4 (0.01-1 microg/mL… CONTINUE READING