Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane.

@article{Zou2010GadoliniumUI,
  title={Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane.},
  author={Jing Zou and Usama Abo Ramadan and Ilmari Pyykk{\"o}},
  journal={Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology},
  year={2010},
  volume={31 4},
  pages={637-41}
}
OBJECTIVE To investigate the inner ear uptake of the contrast agent gadolinium administered intratympanically through transtympanic injection or using a gelatin sponge placed on the round window. MATERIALS AND METHODS The T1 contrast agent Gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) was administrated to the middle ear cavities of 12 male Wistar rats by a transtympanic injection technique (TTI group; 40 microl), gelatin sponge diffusion (GelD40 group; 40 microl), or gelatin… CONTINUE READING