Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice.

Abstract

Detection of amyloid plaques in the brain by in vivo neuroimaging is a very promising biomarker approach for early diagnosis of Alzheimer's disease (AD) and evaluation of therapeutic efficacy. Here we describe a new method to detect amyloid plaques by in vivo magnetic resonance imaging (MRI) based on the intracerebroventricular injection of a nontargeted… (More)
DOI: 10.1016/j.neurobiolaging.2011.03.009

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