Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids.

@article{Ermakov2010GadoliniumIB,
  title={Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids.},
  author={Yury A. Ermakov and Kishore Kamaraju and Krishnendu Sengupta and Sergei Sukharev},
  journal={Biophysical journal},
  year={2010},
  volume={98 6},
  pages={1018-27}
}
Effects of polyvalent ions on the lateral packing of phospholipids have been known for decades, but the physiological consequences have not been systematically studied. Gd(3+) is a relatively nonspecific agent that blocks mechano-gated channels with a variable affinity. In this study, we show that the large mechanosensitive channel MscL of Escherichia coli is effectively blocked by Gd(3+) only when reconstituted with negatively charged phospholipids (e.g., PS). Taking this lead, we studied… CONTINUE READING

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