Gadolinium chelates with weak binding to serum proteins. A new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging.

@article{Cavagna1997GadoliniumCW,
  title={Gadolinium chelates with weak binding to serum proteins. A new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging.},
  author={Friedrich M Cavagna and Fabio Maggioni and P. M. Castelli and Massimo Dapr{\`a} and Luca Imperatori and Vito Lorusso and Bruce G. Jenkins},
  journal={Investigative radiology},
  year={1997},
  volume={32 12},
  pages={780-96}
}
RATIONALE AND OBJECTIVES The authors assess the effect of weak protein binding on the efficacy of gadolinium chelates as contrast agents for magnetic resonance imaging (MRI). METHODS Chelates with no (gadopentetate dimeglumine), weak (gadobenate dimeglumine), and strong (B-21326/7) protein binding were compared by in vitro MRI at 2T (spin echo [SE]: repetition time [TR]/echo time [TE] 350/8 mseconds) on solutions in 0.5 mM bovine serum albumin and in rat whole blood, and by in vivo MRI at 2T… CONTINUE READING

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