Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging.

@article{Alric2008GadoliniumCC,
  title={Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging.},
  author={Christophe Alric and Jacqueline Taleb and G{\'e}raldine Le Duc and C{\'e}line A. Mandon and Claire Billotey and Alice Le Meur-Herland and Thierry Brochard and Francis Vocanson and Marc Janier and Pascal Perriat and St{\'e}phane Roux and Olivier Tillement},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 18},
  pages={5908-15}
}
Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell, whereas the gold core provides a strong X-ray absorption. This study revealed… CONTINUE READING
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