Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling.


In the liver, the JNK cascade is induced downstream of TNF receptors (TNFRs) in response to inflammatory, microbial, and toxic challenges. Sustained activation of JNK triggers programmed cell death (PCD), and hepatocyte survival during these challenges requires induction of the NF-kappaB pathway, which antagonizes this activation by upregulating target… (More)
DOI: 10.1172/JCI33913

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