Gadd45a Is an RNA Binding Protein and Is Localized in Nuclear Speckles

Abstract

BACKGROUND The Gadd45 proteins play important roles in growth control, maintenance of genomic stability, DNA repair, and apoptosis. Recently, Gadd45 proteins have also been implicated in epigenetic gene regulation by promoting active DNA demethylation. Gadd45 proteins have sequence homology with the L7Ae/L30e/S12e RNA binding superfamily of ribosomal… (More)
DOI: 10.1371/journal.pone.0014500

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