Gadd45β is important for perpetuating cognate and inflammatory signals in T cells

  title={Gadd45β is important for perpetuating cognate and inflammatory signals in T cells},
  author={Binfeng Lu and Anthony F Ferrandino and Richard A Flavell},
  journal={Nature Immunology},
Gadd45β (growth arrest and DNA damage–inducible, β) is involved in cell cycle arrest, apoptosis, signal transduction and cell survival. In T cells, Gadd45b was rapidly induced by T cell receptor (TCR) and inflammatory signals. Deficiency of Gadd45β in CD4+ T cells impaired their responses to TCR stimulation or inflammatory cytokines. ERK, p38 and JNK activation were all substantially suppressed in Gadd45β-deficient CD4+ T cells. Cytokine production by Gadd45β-deficient CD4+ T cells was also… CONTINUE READING
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