Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis.

@article{Yoon2004GabexateMI,
  title={Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis.},
  author={W H Yoon and Yeon-Joo Jung and Tae-Dong Kim and Ge Li and Byoung-Jeon Park and Ji-Yeon Kim and Young-Chul Lee and J Kim and Jong-Il Park and Hae-Duck Park and Zae-Sung No and Kyu Je Lim and Byung-Doo Hwang and Young So Kim},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 13},
  pages={4517-26}
}
Gabexate mesilate (GM), a synthetic protease inhibitor, has an antiproteinase activity on various types of plasma serine proteases. However, its role on matrix metalloproteinases (MMPs) has not been identified. In this study, we investigated the effect of GM on MMPs and on the invasion and metastasis of human colon cancer cell lines and neoangiogenesis. The activities of MMPs secreted from these cells were significantly reduced by GM but unaffected by the serine protease inhibitor aprotinin. GM… CONTINUE READING
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