Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro.

Abstract

OBJECTIVE Gabexate mesilate, a synthetic protease inhibitor, has been shown to reduce endotoxin-induced pulmonary vascular injury in an animal model of sepsis by inhibiting leukocyte activation. We examined whether gabexate mesilate inhibits tumor necrosis factor-alpha-induced expression of leukocyte adhesion molecules in cultured endothelial cells… (More)

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@article{Uchiba2003GabexateMA, title={Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro.}, author={Mitsuhiro Uchiba and Kenji Okajima and Christoph Kaun and Bernd Binder and Johann Wojta}, journal={Critical care medicine}, year={2003}, volume={31 4}, pages={1147-53} }