Gabapentina e pregabalina no período perioperatório em cirurgia cardíaca: uma revisão sistemática e metanálise

@article{Maitra2017GabapentinaEP,
  title={Gabapentina e pregabalina no per{\'i}odo perioperat{\'o}rio em cirurgia card{\'i}aca: uma revis{\~a}o sistem{\'a}tica e metan{\'a}lise},
  author={Souvik Maitra and Dalim Kumar Baidya and Sulagna Bhattacharjee and Anirban Som},
  journal={Revista Brasileira De Anestesiologia},
  year={2017},
  volume={67},
  pages={294-304}
}
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TLDR
Gabapentin and pregabalin seem not to have any influence on the prevention of PONV, but comparisons with other standard post-operative regimens are not sufficient.
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Perioperative pregabalin administration reduced opioid consumption and opioid-related adverse effects after surgery, and the risk of visual disturbance was greater.
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A body of work supporting the conclusion that perioperative use of gabapentinoids reduces early postoperative pain and opioid use is described, which may inform a surgeon's or anesthesiologist’s optimization of perioperatively use of these drugs, including choice of agent, dose, timing, and duration of therapy.
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The present study shows that a single oral dose of 150 mg pregabalin given 1 h before surgery attenuated the pressor response to tracheal intubation in adults, but the drug did not show any effect on perioperative opioid consumption and was devoid of side-effects in the given dose.
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