Gabapentin versus vigabatrin as first add-on for patients with partial seizures that failed to respond to monotherapy: a randomized, double-blind, dose titration study. GREAT Study Investigators Group. Gabapentin in Refractory Epilepsy Add-on Treatment.

@article{Lindberger2000GabapentinVV,
  title={Gabapentin versus vigabatrin as first add-on for patients with partial seizures that failed to respond to monotherapy: a randomized, double-blind, dose titration study. GREAT Study Investigators Group. Gabapentin in Refractory Epilepsy Add-on Treatment.},
  author={Martin Lindberger and Martin {\AA}lenius and Lars Fris{\'e}n and Svein Johannessen and Sirkku Larsson and Kristina Malmgren and Torbjōrn Tomson},
  journal={Epilepsia},
  year={2000},
  volume={41 10},
  pages={1289-95}
}
PURPOSE Our objective was to compare the efficacy and safety of gabapentin and vigabatrin as first-line add-on treatment in patients with partial epilepsy. METHODS This was a multicenter, double-blind, randomized dose titration study. After baseline assessment and randomization, the dose could be increased if seizures persisted and reduced if side effects occurred. Health-related quality of life was assessed at baseline and at the end of the study. By a protocol amendment post hoc, all… CONTINUE READING

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