Gabapentin normalizes spinal neuronal responses that correlate with behavior in a rat model of cancer-induced bone pain.

@article{DonovanRodrguez2005GabapentinNS,
  title={Gabapentin normalizes spinal neuronal responses that correlate with behavior in a rat model of cancer-induced bone pain.},
  author={Tansy Donovan-Rodr{\'i}guez and Anthony Henry Dickenson and Catherine E Urch},
  journal={Anesthesiology},
  year={2005},
  volume={102 1},
  pages={132-40}
}
BACKGROUND Cancer-induced bone pain is a major clinical problem for which current treatments lack full efficacy. Gabapentin is licensed for use in neuropathic pain yet is also effective against inflammatory stimuli in animals. METHODS A rat model of cancer-induced bone pain using the MRMT-1 cell line injected into the tibia was established to investigate the efficacy of acute (10, 30, 100 mg/kg) and chronic (30 mg/kg) systemic gabapentin on electrophysiological superficial dorsal horn… CONTINUE READING

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