Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression.

@article{Martin2002GabapentinmediatedIO,
  title={Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression.},
  author={Duncan J Martin and David McClelland and Murray B. Herd and Kathy G. Sutton and Matthew D. Hall and Kevin Y-S Lee and Robert D. Pinnock and Roderick H. Scott},
  journal={Neuropharmacology},
  year={2002},
  volume={42 3},
  pages={353-66}
}
We have used the whole cell patch clamp method and fura-2 fluorescence imaging to study the actions of gabapentin (1-(aminoethyl) cyclohexane acetic acid) on voltage-activated Ca(2+) entry into neonatal cultured dorsal root ganglion (DRG) neurones and differentiated F-11 (embryonic rat DRG x neuroblastoma hybrid) cells. Gabapentin (2.5 microM) in contrast to GABA (10 microM) did not influence resting membrane potential or input resistance. In current clamp mode gabapentin failed to influence… CONTINUE READING
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