Gabapentin inhibits calcium currents in isolated rat brain neurons.

  title={Gabapentin inhibits calcium currents in isolated rat brain neurons.},
  author={Alessandro Stefani and Francesca Spadoni and Giorgio Bernardi},
  volume={37 1},
Gabapentin (1(aminomethyl) cyclohexane acetic acid; GBP) is a recently developed anticonvulsant, for which the mechanism of action remains quite elusive. Besides its possible interaction with glutamate synthesis and/or GABA release, in cerebral membranes gabapentin has been shown to bind directly to the alpha2delta subunit of the calcium channel. Therefore, we have tested the possibility that gabapentin affects high threshold calcium currents in central neurons. Calcium currents were recorded… CONTINUE READING