Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry

@article{Montouris2003GabapentinEI,
  title={Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry},
  author={Georgia D. Montouris},
  journal={Epilepsy \& Behavior},
  year={2003},
  volume={4},
  pages={310-317}
}
  • G. Montouris
  • Published 1 June 2003
  • Medicine, Psychology
  • Epilepsy & Behavior
View on Elsevier
doi.org
131 Citations
Highly Influential Citations
4
Background Citations
30
Methods Citations
1
Results Citations
7

131 Citations

Citation Type

Citation Type

Pregnancy outcomes following gabapentin use
TLDR
The results suggest that although this sample size is not large enough to make any definitive conclusions, gabapentin use in pregnancy does not appear to increase the risk for major malformations and the increased risk for low birth weight and preterm birth require further investigation.
Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy.
Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset
TLDR
In this large population-based study, there was no evidence for an association between gabapentin exposure during early pregnancy and major malformations overall, although there was some evidence of a higher risk of cardiac mal Formations.
Antiepileptic treatment in pregnant women: morphological and behavioural effects.
It is well established that children exposed to antiepileptic drugs (AEDs) in utero have an increased risk of adverse pregnancy outcomes including foetal growth retardation, major congenital…
Use of antiepileptic drugs in pregnancy
  • W. Tatum
  • Medicine, Psychology
    Expert review of neurotherapeutics
  • 2006
TLDR
Although no class 1 outcome data are available, prepregnancy counseling to optimize patient-specific treatment is recommended for women of childbearing potential with epilepsy.
Management of Epilepsy during Pregnancy
TLDR
The common treatment strategy has been to use the appropriate AED for the woman’s seizure disorder as monotherapy in the lowest effective dosage throughout pregnancy, the objective being to use AEDs in such a way that generalised tonic-clonic seizures are avoided but with minimised risks to the fetus, the newborn and the breast-fed infant.
Antiepileptic drugs and pregnancy outcomes
TLDR
The purpose of this document is to review the most commonly used compounds in the treatment of WWE, and to provide information on the latest experimental and human epidemiological studies of the effects of AEDs in the exposed embryos.
Safety of the newer antiepileptic drug oxcarbazepine during pregnancy
  • G. Montouris
  • Medicine
    Current medical research and opinion
  • 2005
TLDR
Compared with newborns in the general population, the newborns of women receiving oxcarbazepine monotherapy during pregnancy do not appear to show an increased risk for malformations, however, the number of pregnancies involving maternal exposure to oxcarbzepine identified by this review is not sufficient to draw definitive conclusions.
Management of epilepsy during pregnancy
TLDR
Based on clinical evidence so far, levetiracetam and lamotrigine have emerged as the safest during pregnancy, although others may also be suitable, and not all polytherapy combinations may be detrimental.
Effect of In Utero Exposure of Gabapentin and Valproic Acid on Skeletal Anomalies in Rat Fetuses
TLDR
It is concluded that maternal exposure of GBP or VPA may adversely affect the development and growth of skeletal system in rat fetuses but skeletal anomalies were found more intense in VPA than GBP.
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