Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry

  title={Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry},
  author={Georgia D. Montouris},
  journal={Epilepsy \& Behavior},
  • G. Montouris
  • Published 1 June 2003
  • Medicine, Psychology
  • Epilepsy & Behavior
Pregnancy outcomes following gabapentin use
The results suggest that although this sample size is not large enough to make any definitive conclusions, gabapentin use in pregnancy does not appear to increase the risk for major malformations and the increased risk for low birth weight and preterm birth require further investigation.
Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy.
Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset
In this large population-based study, there was no evidence for an association between gabapentin exposure during early pregnancy and major malformations overall, although there was some evidence of a higher risk of cardiac mal Formations.
Antiepileptic treatment in pregnant women: morphological and behavioural effects.
It is well established that children exposed to antiepileptic drugs (AEDs) in utero have an increased risk of adverse pregnancy outcomes including foetal growth retardation, major congenital
Use of antiepileptic drugs in pregnancy
  • W. Tatum
  • Medicine, Psychology
    Expert review of neurotherapeutics
  • 2006
Although no class 1 outcome data are available, prepregnancy counseling to optimize patient-specific treatment is recommended for women of childbearing potential with epilepsy.
Management of Epilepsy during Pregnancy
The common treatment strategy has been to use the appropriate AED for the woman’s seizure disorder as monotherapy in the lowest effective dosage throughout pregnancy, the objective being to use AEDs in such a way that generalised tonic-clonic seizures are avoided but with minimised risks to the fetus, the newborn and the breast-fed infant.
Antiepileptic drugs and pregnancy outcomes
The purpose of this document is to review the most commonly used compounds in the treatment of WWE, and to provide information on the latest experimental and human epidemiological studies of the effects of AEDs in the exposed embryos.
Safety of the newer antiepileptic drug oxcarbazepine during pregnancy
  • G. Montouris
  • Medicine
    Current medical research and opinion
  • 2005
Compared with newborns in the general population, the newborns of women receiving oxcarbazepine monotherapy during pregnancy do not appear to show an increased risk for malformations, however, the number of pregnancies involving maternal exposure to oxcarbzepine identified by this review is not sufficient to draw definitive conclusions.
Management of epilepsy during pregnancy
Based on clinical evidence so far, levetiracetam and lamotrigine have emerged as the safest during pregnancy, although others may also be suitable, and not all polytherapy combinations may be detrimental.
Effect of In Utero Exposure of Gabapentin and Valproic Acid on Skeletal Anomalies in Rat Fetuses
It is concluded that maternal exposure of GBP or VPA may adversely affect the development and growth of skeletal system in rat fetuses but skeletal anomalies were found more intense in VPA than GBP.


Guidelines for the care of women with epilepsy
Antiepileptic drug (AED) selection in women of reproductive age should consider efficacy, tolerability, interactions with contraceptive medications, and teratogenicity. Women planning a pregnancy
CPD—Education and self-assessment: Epilepsy and pregnancy
Pregnancies in women with epilepsy are high risk and need careful management by both the medical and obstetric teams due to the increased incidence of complications and adverse outcomes of pregnancy.
The offspring of epileptic mother
Maternal epilepsy is likely to adversely affect the off-spring at its various stages of development amounting to increased morbidity and mortality, and management strategies in the context, of available observation has been discussed.
Management issues for women with epilepsy
WWE face health issues for which there is no available outcome literature to guide decision making, and there is a biologic basis for recommendations concerning contraception, folate supplementation, vitamin K use in pregnancy, breast-feeding, metabolic bone disease, catamenial epilepsy, and reproductive endocrine disorders.
Gabapentin in the Management of Convulsive Disorders
Gabapentin dosing must be optimized on an individual basis to achieve an adequate trial of the drug and obtain the best seizure control, as its therapeutic range is not well characterized.
Women's issues in epilepsy. Menses, childbearing, and more.
  • J. Liporace
  • Medicine, Psychology
    Postgraduate medicine
  • 1997
A variety of special issues arise in caring for women with epilepsy, and a better understanding of these concerns will allow physicians to improve the lives ofWomen with epilepsy.
Women's Issues in the Treatment of Epilepsy
  • J. Bruni
  • Medicine, Psychology
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 1998
The advantages and disadvantages of the new antiepileptic drugs in women remain to be fully established but these new agents allow a wider choice for improved seizure control.
Trends in pregnancies and pregnancy rates by outcome: estimates for the United States, 1976-96.
The teenage pregnancy rate has declined considerably in the 1990's, falling 15 percent from its 1991 high of 116.5 per 1,000 women aged 15-19 years to 98.7 in 1996, and the lowest recorded since 1976.
Gabapentin and lamotrigine in bipolar disorder.
  • S. Botts, J. Raskind
  • Psychology, Biology
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 1999
Preliminary evidence indicates that gabapentin and lamotrigine may be useful for the treatment of bipolar disorder, but these two agents should be reserved for patients with bipolar disorder unresponsive to traditional therapies and for patients who cannot tolerate traditional agents.
Women and epilepsy
Sexual development: effect of epilepsy on physical and sexual development in the female effect of physical andSexual development on epilepsy in thefemale effect of anticonvulsant drugs on physical/sexual development and vice versa practical issues in managing and counselling the adolescent female with epilepsy - before, during and after Menarche.