Gabapentin and vigabatrin increase GABA in the human neocortical slice

@article{Errante2002GabapentinAV,
  title={Gabapentin and vigabatrin increase GABA in the human neocortical slice},
  author={Laura D Errante and Anne Williamson and Dennis D. Spencer and Ognen A. C. Petroff},
  journal={Epilepsy Research},
  year={2002},
  volume={49},
  pages={203-210}
}
The effects of antiepileptic drugs, gabapentin and vigabatrin, on gamma-aminobutyric acid (GABA) concentrations were studied in human (n=14) and rat (n=6) neocortical slice preparations. In this study, neocortical slices were incubated with gabapentin, vigabatrin or no drugs for 3 h in an oxygenated environment. Proton magnetic resonance spectroscopy (MRS) of perchloric acid (PCA) extracts was used to measure GABA concentrations. Vigabatrin increased cellular GABA concentrations in both human… CONTINUE READING

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