Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions.

@article{Gilron2007GabapentinAP,
  title={Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions.},
  author={Ian Gilron},
  journal={Current opinion in anaesthesiology},
  year={2007},
  volume={20 5},
  pages={456-72}
}
  • Ian Gilron
  • Published 2007 in Current opinion in anaesthesiology
PURPOSE OF REVIEW Gabapentin and pregabalin bind to the alpha-2-delta calcium channel subunit and represent a novel analgesic drug class. The evidence base supporting their use for chronic neuropathic and early postsurgical pain is reviewed. RECENT FINDINGS Multiple, large, high-quality trials have demonstrated the safety and efficacy of gabapentin and pregabalin in neuropathic pain. Treatment-related improvement of pain and sleep positively impact upon quality of life. Sedation, dizziness… CONTINUE READING