Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn.

@article{Shimoyama2000GabapentinAG,
  title={Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn.},
  author={Megumi Shimoyama and Naohito Shimoyama and Yuuichi Hori},
  journal={Pain},
  year={2000},
  volume={85 3},
  pages={405-14}
}
We investigated the effects of gabapentin (GBP) on glutamatergic synaptic transmission in the dorsal horn of the rat spinal cord. Patch clamp whole cell recordings were made from superficial and deep dorsal horn neurons of rat spinal cord slices. In the majority of neurons in the superficial lamina, GBP decreased the amplitudes of evoked excitatory postsynaptic currents (evoked EPSCs) mediated by either non-NMDA or NMDA receptors. In contrast, neurons in the deep lamina showed variable effects… CONTINUE READING