Gabapentin Blocks L-Type and P/Q-Type Ca2+ Channels Involved in Depolarization-Stimulated Nitric Oxide Synthase Activity in Primary Cultures of Neurons from Mouse Cerebral Cortex

@article{Oka2003GabapentinBL,
  title={Gabapentin Blocks L-Type and P/Q-Type Ca2+ Channels Involved in Depolarization-Stimulated Nitric Oxide Synthase Activity in Primary Cultures of Neurons from Mouse Cerebral Cortex},
  author={Masuichiro Oka and Yoshinori Itoh and Miyuki Damasceno Wada and Akira Yamamoto and Takuya Fujita},
  journal={Pharmaceutical Research},
  year={2003},
  volume={20},
  pages={897-899}
}
Purpose: The effect of gabapentin [1-(aminomethyl)cyclohexane acetic acid] on Ca2+ channels involving the activation of nitric oxide synthase (NOS) was investigated in primary neuronal culture of mouse cerebral cortex. Methods:The expression of α2δ subunits of Ca2+ channels was investigated by RT-PCR using specific primer sets. The K+-evoked NOS activity was estimated by guanosine 3'5' cyclic monophosphate (cGMP) formation. Results:mRNA for α2δ subunits of Ca2+ channels is found in these cells… CONTINUE READING
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