Gabapentin Administration Reduces Reactive Gliosis and Neurodegeneration after Pilocarpine-Induced Status Epilepticus

@inproceedings{Rossi2013GabapentinAR,
  title={Gabapentin Administration Reduces Reactive Gliosis and Neurodegeneration after Pilocarpine-Induced Status Epilepticus},
  author={Alicia Raquel Rossi and Maria Florencia Angelo and Alejandro Villarreal and Jer{\'o}nimo Lukin and Alberto Javier Ramos},
  booktitle={PloS one},
  year={2013}
}
The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period. It has been proposed that the neuronal network reorganization that occurs during latency determines the subsequent appearance of spontaneous recurrent seizures. The aim of this study was to evaluate neuronal and glial responses during the latency period that follows SE. Given the potential role of astrocytes… CONTINUE READING
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