Corpus ID: 8959463

Gabapentin Abuse and Overdose : A Case Report

@inproceedings{Shebak2014GabapentinAA,
  title={Gabapentin Abuse and Overdose : A Case Report},
  author={Shady S Shebak and Robert J Varipapa and Andrew D Snyder and Megan D Whitham and Thomas R Milam},
  year={2014}
}
The abuse potential of drugs that stimulate dopamine release has driven the search for drugs that influence alternate neurotransmitters, and the glutaminergic pathway is a potential target for the development of new therapeutic practices [1]. Gabapentin is one such drug that modulates GABA and glutamate levels; its clinical effectiveness has been reported across a wide variety of disorders ranging from neuropathic pain and epilepsy to psychiatric disorders. While abuse potential for gabapentin… Expand
2 Citations
A Call for Caution in Prescribing Gabapentin to Individuals With Concurrent Polysubstance Abuse: A Case Report.
TLDR
This case report describes a patient with long-term polysubstance abuse and new onset gabapentin dependence and demonstrates the need for increased surveillance of gABapentin prescribing. Expand
Commentary on "A Call for Caution in Prescribing Gabapentin to Individuals with Concurrent Polysubstance Abuse: A Case Report".
  • D. Kahn
  • Medicine
  • Journal of psychiatric practice
  • 2019
TLDR
This case report describes a patient with long-term polysubstance abuse and new onset gabapentin dependence and demonstrates the need for increased surveillance of gABapentin prescribing. Expand

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TLDR
2 patients who used larger doses of gabapentin than prescribed and who then developed a withdrawal syndrome similar to delirium tremens upon discontinuation of the drug are described. Expand
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TLDR
Gabapentin was tested for its effects on seven enzymes in the metabolic pathways of these two neurotransmitters and exhibited a potent competitive inhibition of both cytosolic and mitochondrial forms of brain BCAA-T, suggesting that gabapentin may significantly reduce synthesis of glutamate from BCAA in brain by acting on BCAA -T. Expand
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Recent troubling experiences in the Florida Department of Corrections involving the intranasal abuse of gabapentin among several inmates with prior histories of cocaine dependence are shared. Expand
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TLDR
A 53-year-old woman had coffee ground emesis, a two-day history of black tarry stools, and abdominal pain, and was presumed to be suffering from ethanol withdrawal and was treated with benzodiazepines but had no improvement in symptoms. Expand
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TLDR
It is demonstrated that nonsynaptic glutamate derived from xc- modulates synaptic glutamate release and thereby regulates cocaine-induced drug seeking. Expand
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TLDR
This study, the first to the authors' knowledge that examines the efficacy and tolerability of a glutamatergic agent in the treatment of trichotillomania, found that N-acetylcysteine demonstrated statistically significant reductions in trichosomatic symptoms. Expand
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A hypothesis is articulated that altered G protein signaling in the PFC focuses behavior on drug-associated stimuli, while dysregulated PFC-accumbens synaptic glutamate transmission underlies the unmanageable motivation to seek drugs. Expand
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  • Shebak SS, Varipapa RJ, Snyder AD, Whitham MD, et al. (2014) Gabapentin Abuse and Overdose: A Case Report. J Subst Abuse Alcohol 2(3): 1018. Cite this article Central Shebak et al. (2014) Email: J Subst Abuse Alcohol 2(3): 1018
  • 2014
Gabapentin Abuse and Overdose : A Case Report
  • 2014
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