Gabapentin: pharmacology and its use in pain management

@article{Rose2002GabapentinPA,
  title={Gabapentin: pharmacology and its use in pain management},
  author={M A Rose and Peter Ca Kam},
  journal={Anaesthesia},
  year={2002},
  volume={57}
}
Summary Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage‐dependent calcium ion channels at the postsynaptic dorsal horns and may, therefore, interrupt the series of events that possibly leads to the experience of a neuropathic pain sensation. Gabapentin is especially effective at relieving allodynia and hyperalgesia in animal models. It has been shown to be efficacious in numerous small clinical studies and case reports in a wide variety of… 
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TLDR
Gabapentin may have advantages over current therapies, such as a favorable safety profile and lack of drug interactions; however, cost issues and limited experience may limit the use of gabapentin as a first-line option.
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TLDR
Gabapentin is an anticonvulsant medication used recently as an effective adjuvant agent for treating neuropathic pain and has desirable pharmacokinetic properties and acceptable side effects, which simplify its use.
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TLDR
It is suggested that gabapentin has preferential antihyperalgesic and/or antiallodynic effects, and is equally effective in pain due to peripheral nerve injuries and central lesions and is particularly effective in reducing paroxysmal pain.
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TLDR
Throbbing pains, pins and needles, and cramping pains responded best, and dull aching pains responded least to the medication, and Mild to moderate side effects were observed.
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TLDR
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TLDR
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BACKGROUND Gabapentin is active in the regulation of facilitated pain states evoked by tissue injury. The mechanism of this action is believed to be through a specific binding site, likely at the
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TLDR
Systemic injections of amitriptyline, gabapentin, or lidocaine produced pain-relieving effects in this established model for neuropathic pain in rats, which supports their clinical use in managing patients with neuropathicPain syndromes.
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  • H. Hansen
  • Medicine
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TLDR
Two patients with interstitial cystitis improved functional capacity within their activities of daily living and received adequate pain control with the addition of gabapentin to their medication regimen.
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