Gabapentin: pharmacokinetics, efficacy, and safety.

  title={Gabapentin: pharmacokinetics, efficacy, and safety.},
  author={Ahmad A Beydoun and Basim M. Uthman and J. Chris Sackellares},
  journal={Clinical neuropharmacology},
  volume={18 6},
Gabapentin is a new antiepileptic drug (AED) with an attractive pharmacokinetic profile. It is absorbed by an active and saturable transport system, and has a high volume of distribution. Gabapentin is not bound to plasma proteins, does not induce hepatic enzymes and is not metabolized. At steady state, it has a half-life of 6-8 h, and is eliminated unchanged by renal route with a plasma clearance proportional to the creatinine clearance. It is devoid of significant drug-drug interactions when… CONTINUE READING


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