Gabapentin: Abuse, Dependence, and Withdrawal.

@article{Mersfelder2016GabapentinAD,
  title={Gabapentin: Abuse, Dependence, and Withdrawal.},
  author={Tracey L Mersfelder and William H. Nichols},
  journal={The Annals of pharmacotherapy},
  year={2016},
  volume={50 3},
  pages={
          229-33
        }
}
OBJECTIVE To identify case reports and studies regarding patients who abused, became dependent on, or experienced withdrawal from gabapentin. DATA SOURCES A PubMed literature search (1993 to October 2015) was performed using the search terms gabapentin, withdrawal, dependence, and addiction. Additional references were identified from a review of literature citations. STUDY SELECTION All English-language case reports and studies were evaluated. DATA SYNTHESIS A total of 18 case reports or… Expand
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78 Citations
Highly Influential Citations
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Background Citations
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Results Citations
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78 Citations

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Citation Type

Reply: Gabapentin: Abuse, Dependence, and Withdrawal.
TLDR
The reply summarizes very well most of the salient points made in the article—namely, that there exists a potential for misuse of gabapentin, especially among patients with other substanceabuse issues and that withdrawal symptoms may result after abrupt cessation. Expand
[On the risk of dependence on gabapentinoids].
TLDR
It is thought that in patients with current or past substance use disorders, the treatment with gabapentinoids should be avoided or if indispensable, these drugs should be administered exclusively over a limited time span with caution by using a therapeutic and prescription monitoring. Expand
Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update
TLDR
Evidence suggests that gabapentinoid misuse/abuse represents a growing trend that is causing significant patient harm, and prescribers should exercise appropriate caution with use in high-risk populations and monitor for signs of misuse or abuse. Expand
Comment: Gabapentin
TLDR
The view that the addiction risk of gabapentin is negligible in patients without a history of SUD is supported, and a larger systematic clinical trial investigating the addictive risk of GABapentin in patients with and without a relation to another Sud is warranted. Expand
Gabapentin abuse: A case presentation on how to manage this growing concern
TLDR
Clinicians must understand that gabapentin is not effective for a variety of pain conditions nor is a routine substitute for opioids, and close monitoring practices often associated with opioids and benzodiazepines should be applied to that of gabAPentin. Expand
Exploration of the Misuse, Abuse, and Diversion of Gabapentin
TLDR
This dissertation assesses the etiology and prevalence of gabapentin misuse, abuse, and diversion in a multi-faceted approach, namely by the individual, ecological, and pharmacoepidemiological factors associated with this phenomenon. Expand
On the addictive power of gabapentinoids: a mini-review.
TLDR
The view that gabapentinoids are quite rarely addictive in the general population is supported, however, in patients with a history of SUD, gabAPentinoids (notably pregabalin) should avoided or, if thought to be beneficial, administered with caution by using a strict prescription and therapy monitoring. Expand
How addictive are gabapentin and pregabalin? A systematic review
TLDR
The addiction risks of gabapentin and pregabalin are compared with those of traditional psychoactive substances and recommend that in patients with a history of SUD, gabAPentinoids should be avoided or if indispensable, administered with caution by using a strict therapeutic and prescription monitoring. Expand
A Qualitative Analysis of Gabapentin Misuse and Diversion Among People Who Use Drugs in Appalachian Kentucky
TLDR
Focus group responses highlighted the low cost of gabapentin for the purpose of getting high and noted increasing popularity in the community, particularly over the last 2 years, and a reexamination of the need for scheduling is warranted. Expand
Gabapentinoid Use Disorder: Update for Clinicians
Citation: Pergolizzi., et al. “Gabapentinoid Use Disorder: Update for Clinicians”. EC Anaesthesia 4.8 (2018): 303-317. Abstract Gabapentinoids (gabapentin and pregabalin) are versatile drugs,… Expand
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References

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Gabapentin withdrawal syndrome in the presence of a taper.
TLDR
It is proposed herein that a gabapentin taper should follow a course similar to that of a benzodiazepine taper -- slowly and over a period of weeks to months. Expand
Gabapentin abuse, and delirium tremens upon gabapentin withdrawal.
TLDR
2 patients who used larger doses of gabapentin than prescribed and who then developed a withdrawal syndrome similar to delirium tremens upon discontinuation of the drug are described. Expand
Gabapentin-Induced Delirium and Dependence
TLDR
The case described here involving a 38-year-old male physician with substance intoxication delirium and psychoactive substance dependence due to high self-administered doses of gabapentin suggests the need for heightened concern regarding the off-label prescription of this drug to vulnerable individuals with psychiatric conditions. Expand
Akathisia Induced by Gabapentin Withdrawal
TLDR
If gabapentin discontinuation is desired, it is prudent to gradually taper the dose to avoid withdrawal symptoms, which may occur after as little as 1 month of treatment. Expand
Withdrawal symptoms after gabapentin discontinuation.
TLDR
A 53-year-old woman had coffee ground emesis, a two-day history of black tarry stools, and abdominal pain, and was presumed to be suffering from ethanol withdrawal and was treated with benzodiazepines but had no improvement in symptoms. Expand
Abuse of combinations of gabapentin and quetiapine.
TLDR
Evidence exists for abuse of both gabapentin and quetiapine, which has been removed from several prison formularies because of abuse by inmates, and patients should exercise vigilance when using either to treat patients who use alcohol or illicit drugs. Expand
Gabapentinoid Abuse in Order to Potentiate the Effect of Methadone: A Survey among Substance Misusers
Background/Aims: There is emerging evidence of gabapentin and pregabalin (gabapentinoid) abuse, particularly in the substance misuse population, and some suggestion of gabapentinoids being abused… Expand
Prescription medication misuse among opioid dependent patients seeking inpatient detoxification.
TLDR
High rates of medication misuse in opioid dependent patients admitted for detoxification was found and appeared similar to rates of misuse among controlled substances such as clonazepam and amphetamine salts. Expand
Neonatal Gabapentin Withdrawal Syndrome.
TLDR
A newborn who showed signs of withdrawal after prolonged in utero exposure to gabapentin is presented and Clinicians should be aware of possible withdrawal symptoms from drugs such as gapapentin, administered to mothers during pregnancy. Expand
Misuse of the γ-aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK.
TLDR
The aim of this study was to determine the prevalence, frequency and sources of misuse of the GABA analogues (baclofen, gabapentin and pregabalin) in the UK, and to benchmark against existing national data provided by the 2011/2012 Crime Survey for England and Wales. Expand
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