Gabapentin: Abuse, Dependence, and Withdrawal.

  title={Gabapentin: Abuse, Dependence, and Withdrawal.},
  author={Tracey L. Mersfelder and William H. Nichols},
  journal={The Annals of pharmacotherapy},
  volume={50 3},
OBJECTIVE To identify case reports and studies regarding patients who abused, became dependent on, or experienced withdrawal from gabapentin. DATA SOURCES A PubMed literature search (1993 to October 2015) was performed using the search terms gabapentin, withdrawal, dependence, and addiction. Additional references were identified from a review of literature citations. STUDY SELECTION All English-language case reports and studies were evaluated. DATA SYNTHESIS A total of 18 case reports or… 

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Reply: Gabapentin: Abuse, Dependence, and Withdrawal.

The reply summarizes very well most of the salient points made in the article—namely, that there exists a potential for misuse of gabapentin, especially among patients with other substanceabuse issues and that withdrawal symptoms may result after abrupt cessation.

[On the risk of dependence on gabapentinoids].

It is thought that in patients with current or past substance use disorders, the treatment with gabapentinoids should be avoided or if indispensable, these drugs should be administered exclusively over a limited time span with caution by using a therapeutic and prescription monitoring.

Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update

Evidence suggests that gabapentinoid misuse/abuse represents a growing trend that is causing significant patient harm, and prescribers should exercise appropriate caution with use in high-risk populations and monitor for signs of misuse or abuse.

Comment: Gabapentin

The view that the addiction risk of gabapentin is negligible in patients without a history of SUD is supported, and a larger systematic clinical trial investigating the addictive risk of GABapentin in patients with and without a relation to another Sud is warranted.

Gabapentin abuse: A case presentation on how to manage this growing concern

Clinicians must understand that gabapentin is not effective for a variety of pain conditions nor is a routine substitute for opioids, and close monitoring practices often associated with opioids and benzodiazepines should be applied to that of gabAPentin.

Gabapentin dependence and withdrawal requiring an 18-month taper in a patient with alcohol use disorder: a case report

This case highlights the need for patient-centered slow tapers in patients with severe gabapentin dependence and withdrawal, and presents a 32-year-old female effectively treated for AUD with 1,200 mg daily dose of gABapentin, who developed gabAPentin dependenceand severe withdrawal.

Exploration of the Misuse, Abuse, and Diversion of Gabapentin

This dissertation assesses the etiology and prevalence of gabapentin misuse, abuse, and diversion in a multi-faceted approach, namely by the individual, ecological, and pharmacoepidemiological factors associated with this phenomenon.

On the addictive power of gabapentinoids: a mini-review.

The view that gabapentinoids are quite rarely addictive in the general population is supported, however, in patients with a history of SUD, gabAPentinoids (notably pregabalin) should avoided or, if thought to be beneficial, administered with caution by using a strict prescription and therapy monitoring.

How addictive are gabapentin and pregabalin? A systematic review


The Role of Gabapentin in the Management of Alcohol Withdrawal and Dependence

Limited data suggest that gabapentin can provide benefit in managing mild alcohol withdrawal syndrome, and future studies should focus on adequate dosing strategies.

Gabapentin withdrawal syndrome in the presence of a taper.

It is proposed herein that a gabapentin taper should follow a course similar to that of a benzodiazepine taper -- slowly and over a period of weeks to months.

Gabapentin abuse, and delirium tremens upon gabapentin withdrawal.

2 patients who used larger doses of gabapentin than prescribed and who then developed a withdrawal syndrome similar to delirium tremens upon discontinuation of the drug are described.

Gabapentin-Induced Delirium and Dependence

The case described here involving a 38-year-old male physician with substance intoxication delirium and psychoactive substance dependence due to high self-administered doses of gabapentin suggests the need for heightened concern regarding the off-label prescription of this drug to vulnerable individuals with psychiatric conditions.

Akathisia Induced by Gabapentin Withdrawal

If gabapentin discontinuation is desired, it is prudent to gradually taper the dose to avoid withdrawal symptoms, which may occur after as little as 1 month of treatment.

Withdrawal symptoms after gabapentin discontinuation.

A 53-year-old woman had coffee ground emesis, a two-day history of black tarry stools, and abdominal pain, and was presumed to be suffering from ethanol withdrawal and was treated with benzodiazepines but had no improvement in symptoms.

Abuse of combinations of gabapentin and quetiapine.

  • R. ReevesR. Burke
  • Psychology, Medicine
    The primary care companion for CNS disorders
  • 2014
Evidence exists for abuse of both gabapentin and quetiapine, which has been removed from several prison formularies because of abuse by inmates, and patients should exercise vigilance when using either to treat patients who use alcohol or illicit drugs.

Gabapentinoid Abuse in Order to Potentiate the Effect of Methadone: A Survey among Substance Misusers

Background/Aims: There is emerging evidence of gabapentin and pregabalin (gabapentinoid) abuse, particularly in the substance misuse population, and some suggestion of gabapentinoids being abused

Prescription medication misuse among opioid dependent patients seeking inpatient detoxification.

High rates of medication misuse in opioid dependent patients admitted for detoxification was found and appeared similar to rates of misuse among controlled substances such as clonazepam and amphetamine salts.

Neonatal Gabapentin Withdrawal Syndrome.