Gabapentin, A GABA analogue, enhances cognitive performance in mice

@article{Celikyurt2011GabapentinAG,
  title={Gabapentin, A GABA analogue, enhances cognitive performance in mice},
  author={I. Celikyurt and O. Mutlu and G. Ulak and F. Akar and F. Erden},
  journal={Neuroscience Letters},
  year={2011},
  volume={492},
  pages={124-128}
}
Gabapentin is one of the new antiepileptic drugs (AEDs) launched recently. The advantage of new AEDs includes newer mechanism of action, broad spectrum of antiseizure effects, lesser drug interactions and fewer side effects. Gabapentin (GBP) a GABA analogue, is efficacious in several neurological and psychiatric conditions and it is conventionally used in the treatment of partial epilepsies. In this study, we aimed to evaluate the effects of GBP on learning and memory processes of naive mice in… Expand
EVALUATION OF CHRONIC AND ACUTE EFFECTS OF GABAPENTIN ON PASSIVE AVOIDANCE LEARNING PROCESS IN MICE
TLDR
GBP exerted no destructive effects on cognition; however, it improved emotional cognitive performance in mice in PA tasks and increased Step Through Latency (STL), showing the enhancement of memory. Expand
Lamotrigine, a mood stabilizer, may have beneficial effects on memory acquisition and retrieval in mice.
TLDR
The results may indicate that, LMG may have some ameliorating effects on spatial memory retrieval on the MWM test and positively affected the acquisition of memory in the mEPM and in the PA test in naive mice. Expand
Positive impact of levetiracetam on emotional learning and memory in naive mice.
TLDR
The results indicate that LEV did not alter spatial memory retrieval in the MWM test, but it did show some ameliorating effects on acquisition and memory formation in the PA test in naive mice. Expand
The effect of lamotrigine on learning in mice using the passive avoidance model
TLDR
LTG at higher doses may facilitate the learning process in mice and appears to improve memory function at different stages, according to the retention latency times. Expand
Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats
TLDR
The impact of immediate and delayed treatment with intracerebroventricular drugs on cognition and behavior seems to be quite similar. Expand
Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: Possible behavioral, biochemical and mitochondrial alterations
TLDR
Hesp possesses potent anticonvulsant activity which might be mediated through modulation of gamma-amino butyric acid/benzodiazepine receptor action, which was significant as compared to their effects in PTZ treated animals. Expand
Enhanced learning and memory in GAT1 heterozygous mice.
TLDR
GAT1(+/-) mice displayed increased learning and memory, decreased anxiety-like behaviors, and highest synaptic plasticity compared with wild-type and homozygous GAT1(-/-) dogs, suggesting that a moderate reduction in Gat1 activity causes the enhancement of learning andMemory in mice. Expand
Assessment of combined treatment with vigabatrin and antihypertensive drugs against electroconvulsions in mice
TLDR
From the preclinical point of view, the use of the tested antihypertensive drugs in patients treated with VGB seems neutral regarding its anticonvulsant activity. Expand
Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome
TLDR
The results suggest that KCNJ6 may not be a promising drug target candidate in DS and show that long-term use of ETH and GAB is devoid of adverse behavioral and cognitive effects. Expand
Activation of extrasynaptic GABAA receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons
TLDR
The results suggest that the CTZ-induced epileptiform activity in hippocampal CA1 neurons is suppressed by the activation of extrasynaptic GABAARs, and further support the hypothesis that tonic inhibition mediated by Extrasynaptic GABAARs plays a prominent role in seizure generation. Expand
...
1
2
...

References

SHOWING 1-10 OF 31 REFERENCES
Gabapentin, an antiepileptic drug, improves memory storage in mice
TLDR
The results suggest that GBP influences retention by modulating time-dependent processes involved in memory storage, although the mechanism(s) of this action remain to be established. Expand
Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain
TLDR
The data suggest that an effect of gabapentin on GABA synthesis might be involved in its mechanism of anticonvulsant action. Expand
Memory improving actions of gabapentin in mice: possible involvement of central muscarinic cholinergic mechanism
TLDR
Findings suggest a disinhibitory action of GBP on the activity of central muscarinic cholinergic mechanisms that are involved in memory consolidation in CF-1 mice. Expand
Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice
TLDR
The results suggest that a combined treatment with a 5-HT(4) receptor agonist with an acetylcholinesterase inhibitor has beneficial effects on memory in mice and seems to enhance sAPPalpha levels in two brain regions highly affected in AD. Expand
Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in rats.
TLDR
Results showed that lamotrigine did not produce any change in cognitive function, while carbamazepine produced cognitive dysfunction, and oxidative stress in brain during chemically induced epileptogenesis in rats was significantly decreased. Expand
COGNITIVE SIDE EFFECTS OF ANTIEPILEPTIC DRUGS
Available studies of the cognitive side effects of traditional and newer antiepileptic drugs (AEDs) are reviewed by researchers at Georgetown University Medical Center, Washington, DC. Relatively fewExpand
Gabapentin and cognition: a double blind, dose ranging, placebo controlled study in refractory epilepsy.
TLDR
GBP is a well tolerated and effective antiepileptic drug which had no measurable effect on cognition but did produce sedation at the highest dose, and supports the suggestion that seizures can cause cognitive impairment. Expand
Effects of topiramate and gabapentin on cognitive abilities in healthy volunteers
TLDR
Topiramate (TPM) impaired cognitive test performance, whereas gabapentin had minimal effects, and the effects of TPM were of sufficient magnitude potentially to affect daily and occupational function. Expand
Gabapentin dosing in the treatment of epilepsy.
TLDR
The authors' review of this literature suggests improved seizure control at higher gabapentin maintenance dosages than are used today in clinical practice without an increase in the incidence of adverse reactions. Expand
Valproic acid reduces spatial working memory and cell proliferation in the hippocampus
TLDR
Treatment of rats by i.p. injection of VPA reduced cell proliferation in the sub granular zone of the dentate gyrus within the hippocampus, and this was linked to a significant impairment in their ability to perform a hippocampus-dependent spatial memory test. Expand
...
1
2
3
4
...