Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential

@article{Bardelli1997Gab1CT,
  title={Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential},
  author={Alberto Bardelli and Paola Longati and Daniela Gramaglia and Maria Cristina Stella and Paolo Maria Comoglio},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={3103-3111}
}
Activation of the HGF receptor, encoded by the c-MET protooncogene (Met receptor), triggers motility, matrix-invasion and branching morphogenesis in epithelial cells. It has recently been shown that the Met receptor interacts with Gab-1, an IRS-like adaptor protein, via the docking site (Y1349VHVNATY1356VNV) known to bind Grb2 and multiple SH2-containing signal transducers. Here we show that Gab1 is the major phosphorylation-substrate of the Met receptor and of its oncogenic variant Tpr-Met. A… CONTINUE READING
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