GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses

@article{Donevan1993GYKI5A,
  title={GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses},
  author={Sean D. Donevan and Michael A. Rogawski},
  journal={Neuron},
  year={1993},
  volume={10},
  pages={51-59}
}
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1 The 2,3‐benzodiazepines GYKI 52466, GYKI 53405 and GYKI 53655 antagonized AMPA‐induced currents in cultured superior colliculus neurones in a non use‐dependent manner (steady state IC50S: GYKI…
Effects of the non‐NMDA antagonists NBQX and the 2,3‐benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil
TLDR
The data indicate that the GABAA receptor‐associated benzodiazepine site is not critically involved in anticonvulsant or adverse effects of GYKI 52466, and demonstrates that non‐NMDA antagonists lack a selective anticonVulsant action in standard models of generalized seizures.
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