GWIS - model-free, fast and exhaustive search for epistatic interactions in case-control GWAS

@inproceedings{Goudey2013GWISM,
  title={GWIS - model-free, fast and exhaustive search for epistatic interactions in case-control GWAS},
  author={Benjamin Goudey and David Rawlinson and Qiao Wang and Fan Shi and Herman L. Ferr{\'a} and Richard M. Campbell and Linda Stern and Michael Inouye and Cheng Soon Ong and Adam Kowalczyk},
  booktitle={BMC Genomics},
  year={2013}
}
It has been hypothesized that multivariate analysis and systematic detection of epistatic interactions between explanatory genotyping variables may help resolve the problem of "missing heritability" currently observed in genome-wide association studies (GWAS). However, even the simplest bivariate analysis is still held back by significant statistical and… CONTINUE READING

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