GWAS risk factors in Parkinson's disease: LRRK2 coding variation and genetic interaction with PARK16.

  title={GWAS risk factors in Parkinson's disease: LRRK2 coding variation and genetic interaction with PARK16.},
  author={Alexandra I. Soto-Ortolaza and Michael G Heckman and Catherine Labb{\'e} and Daniel J. Serie and Andreas Puschmann and S. R. Pavan Kumar. Rayaprolu and Audrey J. Strongosky and Magdalena Boczarska-Jedynak and Grzegorz M Opala and Anna Krygowska-Wajs and Maria Barcikowska and Krzysztof Czyżewski and Timothy Lynch and Ryan J. Uitti and Zbigniew K Wszolek and Owen A. Ross},
  journal={American journal of neurodegenerative disease},
  volume={2 4},
Parkinson's disease (PD) is a multifactorial movement disorder characterized by progressive neurodegeneration. Genome-wide association studies (GWAS) have nominated over fifteen distinct loci associated with risk of PD, however the biological mechanisms by which these loci influence disease risk are mostly unknown. GWAS are only the first step in the identification of disease genes: the specific causal variants responsible for the risk within the associated loci and the interactions between… CONTINUE READING
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