GWAS for executive function and processing speed suggests involvement of the CADM2 gene

  title={GWAS for executive function and processing speed suggests involvement of the CADM2 gene},
  author={Carla A. Ibrahim-Verbaas and Jan Bressler and St{\'e}phanie Debette and Maaike Schuur and Albert Vernon Smith and Joshua C Bis and Gail Davies and Stella Trompet and Jennifer A. Smith and Christiane Wolf and Lori B. Chibnik and Yongmei Liu and Veronique Vitart and Mirna Kirin and Katja Petrovic and Ozren Pola{\vs}ek and Lina Zgaga and C Fawns-Ritchie and Per Hoffmann and Juha Karjalainen and Jari Lahti and David J. Llewellyn and Carsten Oliver Schmidt and Karen Mather and Vincent Chouraki and Qianwen Sun and Susan M. Resnick and Lynda M. Rose and Christopher Oldmeadow and Marlene Stewart and Blair H Smith and Vilmundur Gudnason and Qiong Yang and Saira Saeed Mirza and Jan Wouter Jukema and Philip L. DeJager and Tamar B Harris and D C M Liewald and Najaf Amin and Laura H. Coker and Oliver Stegle and O L L{\'o}pez and Reinhold Schmidt and Alexander Teumer and Ian Ford Ford and Nazanin Karbalai and James T. Becker and Mar{\'i}a K J{\'o}nsd{\'o}ttir and Rhoda Au and Rudolf S. N. Fehrmann and Stefan Herms and Mike A. Nalls and Wei Zhao and Steven T Turner and Kristine Yaffe and Kurt Lohman and John van Swieten and Sharon L. R. Kardia and Davis S. Knopman and William M Meeks and Gerardo Heiss and Elizabeth G. Holliday and Peter William Schofield and Toshiko Tanaka and David Stott and J C Wang and Paul Ridker and Alan J. Gow and Alison Pattie and J M Starr and Lynne J. Hocking and Nicola J Armstrong and Stela McLachlan and Joshua M Shulman and Luke C Pilling and Guðn{\'y} Eir{\'i}ksd{\'o}ttir and Rodney J. Scott and Nicole A. Kochan and Aarno V Palotie and Y-C Hsieh and Johan G Eriksson and Alan D. Penman and Rebecca F. Gottesman and Ben A. Oostra and Lei Yu and Anita L. DeStefano and Alexa L Beiser and Mart{\'i}n Garc{\'i}a and Jerome I. Rotter and Markus M. N{\"o}then and Albert Hofman and Pieternella E Slagboom and Rudi G. J. Westendorp and Brendan M. Buckley and Philip A. Wolf and Andr{\'e} G. Uitterlinden and Bruce M. Psaty and Hans J{\"o}rgen Grabe and Stefania Bandinelli and Daniel Chasman and Fran Grodstein and Katri R{\"a}ikk{\"o}nen and J. Lambert and David J. Porteous and Jack Price and Perminder S. Sachdev and Luigi Ferrucci and John R Attia and Igor Rudan and Caroline Hayward and A F Wright and James F Wilson and Sven Cichon and Lude Franke and Helena Schmidt and Jingzhong Ding and Anton J. M. de Craen and Myriam Fornage and David A. Bennett and Ian J. Deary and M. Arfan Ikram and Lenore J. Launer and Annette L. Fitzpatrick and Saurav Seshadri and Cornelia M. van Duijn and Thomas H. Mosley},
  journal={Molecular Psychiatry},
To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429–32 070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the… CONTINUE READING
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