GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers

@inproceedings{Li2012GWASIN,
  title={GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers},
  author={Shengping Li and Ji Qian and Yuan Yang and Wanting Zhao and Juncheng Dai and Jin-Xin Bei and Jia Nee Foo and Paul J. McLaren and Zhiqiang Li and Jingmin Yang and Feng Shen and Li Liu and Jia-mei Yang and Shuhong Li and Shandong Pan and Yi Wang and Wenjin Jason Li and X. Zhai and Bo-ping Zhou and Lehua Shi and Xinchun Chen and Minjie Chu and Yiqun Yan and Jun Wang and Shuqun Cheng and Jiawei Shen and Weihua Jia and Jibin Liu and Jiahe Yang and Zujia Wen and Ai-jun Li and Ying Zhang and Guoliang Zhang and Xianrong Luo and Hongbo Qin and Minshan Chen and Hua Wang and Li Jin and Dongxin Lin and Hongbing Shen and Lin He and Paul I W de Bakker and Hongyang Wang and Yi-xin Zeng and Meng-chao Wu and Zhibin Hu and Yongyong Shi and Jianping Liu and Weiping Zhou},
  booktitle={PLoS genetics},
  year={2012}
}
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). To further identify novel susceptibility loci associated with HBV-related HCC and replicate the previously reported association, we performed a large three-stage GWAS in the Han Chinese population. 523,663 autosomal SNPs in 1,538 HBV-positive HCC patients and 1,465 chronic HBV carriers were genotyped for the discovery stage. Top… CONTINUE READING

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