GWAS Follow-up Study Discovers a Novel Genetic Signal on 10q21.2 for Atopic Dermatitis in Chinese Han Population

@article{Cai2019GWASFS,
  title={GWAS Follow-up Study Discovers a Novel Genetic Signal on 10q21.2 for Atopic Dermatitis in Chinese Han Population},
  author={Xingjun Cai and Lu Cheng and Chong-xian Yu and Yan-Yan Wu and Ling Fang and Xiao-dong Zheng and Fusheng Zhou and Yuming Sheng and Jun Zhu and Jie Zheng and Yuan-yuan Wu and Fengli Xiao},
  journal={Frontiers in Genetics},
  year={2019},
  volume={10}
}
Atopic dermatitis (AD) is a common inflammatory skin disease with high heritability. Two susceptibility loci have been confirmed in our previous AD genome-wide association study (GWAS). To look for additional genetic factors in Chinese Han ethnicity, we performed a large-scale GWAS follow-up study. Forty-nine top single nucleotide polymorphisms (SNPs) that had never been reported previously were genotyped using Sequenom Massarray system in an independent cohort, which consist of northern… 

Figures and Tables from this paper

Validation of Susceptibility Loci for Vitiligo Identified by GWAS in the Chinese Han Population

TLDR
A strong association of 2q24.2, 19p13.3, and 22q13.2 (rs3747517), rs4807000, rs6510827, and rs4822024 are involved in regulating gene expression in the Chinese Han population, which implicates common factors for vitiligo across different ethnicities, and helps expand the understanding of the genetic basis of this disease.

Genetic, Clinical, and Environmental Factors Associated With Persistent Atopic Dermatitis in Childhood

TLDR
In a birth cohort of children at risk for asthma who received close clinical follow-up to age 13 years, known genetic AD risk variants, paternal asthma and AD, high social circumstances, diagnostic minor criteria, and disease severity at onset were associated with persistent AD at age13 years.

References

SHOWING 1-10 OF 39 REFERENCES

Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus.

TLDR
A large-scale replication study based on the previous genome-wide association study of SLE in the Chinese Han population provided novel insights into the genetic architecture of Sle and emphasized the contribution of multiple variants of modest effect.

META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES IDENTIFIES THREE NEW RISK LOCI FOR ATOPIC DERMATITIS

TLDR
A genome-wide association meta-analysis of affected individuals and controls and the ten most strongly associated new susceptibility loci examined underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.

Discovery of a novel genetic susceptibility locus on X chromosome for systemic lupus erythematosus

TLDR
This study increases the number of established susceptibility loci for SLE in Han Chinese population and has further demonstrated the important role of X-linked genetic risk variants in the pathogenesis of Sle in Chinese Han population.

Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population

TLDR
This study identifies new genetic susceptibility factors and suggests previously unidentified biological pathways in atopic dermatitis, which is a chronic, relapsing form of inflammatory skin disorder that is affected by genetic and environmental factors.

A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis

TLDR
It is indicated that the pathogenesis of AD incorporates immune and epidermal barrier defects with combinations of specific and overlapping effects at individual loci, and the genetic relationship between AD, asthma and psoriasis is explored by examining previously identified susceptibility SNPs for these diseases.

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

TLDR
The findings advance the understanding of the genetic basis of atopic dermatitis and replicate the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals.

Genome-wide association study of recalcitrant atopic dermatitis in Korean children.

Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

TLDR
Ten new risk loci are identified for atopic dermatitis, bringing the total number of known atopic skin disease susceptibility loci to 31 (with new secondary signals at four of these loci), underscoring the important contribution of (auto)immune mechanisms to atopy dermatitis pathogenesis.

Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet’s disease susceptibility

TLDR
The findings extend the list of susceptibility genes shared with Crohn's disease and leprosy and implicate mucosal factors and the innate immune response to microbial exposure in Behçet's disease susceptibility.