GVS-111 prevents oxidative damage and apoptosis in normal and Down’s syndrome human cortical neurons

  title={GVS-111 prevents oxidative damage and apoptosis in normal and Down’s syndrome human cortical neurons},
  author={Alejandra Pelsman and Carlos Hoyo-Vadillo and Tatiana A Gudasheva and Sergei B Seredenin and Jorge A. Busciglio},
  journal={International Journal of Developmental Neuroscience},
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons treated with H(2)O(2), and Down's syndrome (DS) cortical neurons. Incubation of normal cortical neurons with 50 microM H(2)O(2) for 1h resulted in morphological and structural changes consistent with… CONTINUE READING
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