GVS-111 prevents oxidative damage and apoptosis in normal and Down’s syndrome human cortical neurons

  title={GVS-111 prevents oxidative damage and apoptosis in normal and Down’s syndrome human cortical neurons},
  author={A. Pelsman and C. Hoyo-Vadillo and T. A. Gudasheva and S. Seredenin and J. Busciglio},
  journal={International Journal of Developmental Neuroscience},
  • A. Pelsman, C. Hoyo-Vadillo, +2 authors J. Busciglio
  • Published 2003
  • Chemistry, Medicine
  • International Journal of Developmental Neuroscience
  • The neuroprotective activity of a novel N‐acylprolyl‐containing dipeptide analog of the nootropic 2‐oxo‐1‐pyrrolidine acetamide (Piracetam) designated as GVS‐111 (DVD‐111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons treated with H2O2, and Down's syndrome (DS) cortical neurons. Incubation of normal cortical neurons with 50 μM H2O2 for 1 h resulted in morphological and structural changes consistent with neuronal… CONTINUE READING
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