GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae.

@article{Holst2000GUP1AI,
  title={GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae.},
  author={Bj\orn Holst and China Lunde and Fernanda Lages and Rui Oliveira and C{\^a}ndida Lucas and Morten C. Kielland-Brandt},
  journal={Molecular microbiology},
  year={2000},
  volume={37 1},
  pages={108-24}
}
Many yeast species can utilize glycerol, both as a sole carbon source and as an osmolyte. In Saccharomyces cerevisiae, physiological studies have previously shown the presence of an active uptake system driven by electrogenic proton symport. We have used transposon mutagenesis to isolate mutants affected in the transport of glycerol into the cell. Here we present the identification of YGL084c, encoding a multimembrane-spanning protein, as being essential for proton symport of glycerol into S… CONTINUE READING
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