GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.

@article{MacAskill2009GTPaseDR,
  title={GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.},
  author={Andrew F. MacAskill and Kieran Brickley and F Anne Stephenson and Josef T Kittler},
  journal={Molecular and cellular neurosciences},
  year={2009},
  volume={40 3},
  pages={301-12}
}
The transport of mitochondria to specific neuronal locations is critical to meet local cellular energy demands and for buffering intracellular calcium. A critical role for kinesin motor proteins in mitochondrial transport in neurons has been demonstrated. Currently however the molecular mechanisms that underlie the recruitment of motor proteins to mitochondria, and how this recruitment is regulated remain unclear. Here we show that a protein trafficking complex comprising the adaptor protein… CONTINUE READING
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