GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.

@article{Biosa2013GTPaseAR,
  title={GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.},
  author={Alice Biosa and Al{\vz}beta Tran{\vc}{\'i}kov{\'a} and Laura Civiero and Liliane Glauser and Luigi Bubacco and Elisa Greggio and Darren Moore},
  journal={Human molecular genetics},
  year={2013},
  volume={22 6},
  pages={1140-56}
}
Mutations in the LRRK2 gene cause autosomal dominant Parkinson's disease. LRRK2 encodes a multi-domain protein containing a Ras-of-complex (Roc) GTPase domain, a C-terminal of Roc domain and a protein kinase domain. LRRK2 can function as a GTPase and protein kinase, although the interplay between these two enzymatic domains is poorly understood. Although guanine nucleotide binding is critically required for the kinase activity of LRRK2, the contribution of GTP hydrolysis is not known. In… CONTINUE READING

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