GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback.

@article{Liu2010GTPaseRacED,
  title={GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback.},
  author={Ruisheng Liu and Luis A Juncos},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2010},
  volume={298 2},
  pages={R453-8}
}
Superoxide (O(2)(-) ) enhances tubuloglomerular feedback (TGF) by scavenging nitric oxide at the macula densa (MD). The primary source of O(2)(-) in the MD during TGF is NADPH oxidase, which is activated by membrane depolarization. While Rac, a small GTP-binding protein, has been shown to enhance NADPH oxidase activity, its role in O(2)(-) generation by the MD is unknown. We hypothesized that depolarization of the MD leads to translocation of Rac to the apical membrane, and its activation, in… CONTINUE READING